Can phenytoin be given via NG tube?

Can phenytoin be given via NG tube?

Nonionized phenytoin is irreversibly bound to NG tubing from solution at the pH of enteral nutrient solutions while this is not the case for anionic phenytoin in unbuffered water or saline.

Which drugs can be given via NG tube?

Table 3

Drugs Proportion of medical orders involving NGT dosing
Potassium chloride SR tablets 719 (1.5%)
Tamsulosin hydrochloride SR capsules (Harnal®) 232 (2.4%)
Isosorbide mononitrate SR tablets 213 (1.2%)
Felodipine SR tablets (Plendil® 2.5 mg) 187 (12.3%)

Can you crush phenytoin?

Do not crush or chew. Take this medicine with food if it upsets your stomach. It may be best to take your medicine consistently with or without food.

Is Dilantin compatible with enteral feedings?

Hypothesis: Dilantin levels will remain therapeutic when enteral nutrition is given continuously during the administration of enteral Dilantin. The objective of this study is to determine Dilantin levels when enteral feedings are given by the continuous method.

What should you flush phenytoin NG with?

Flush the feeding tubes with saline before and after phenytoin administration. In these situations it is recommended to prescribe phenytoin as a single daily dose9,10,. See section 5 for advice on therapeutic drug monitoring for patients on maintenance therapy. dosing can result in a large change in blood levels.

What types of medications Cannot be given via an enteral tube?

Some liquid formulations are not appropriate for administration via the enteral tube. These include lansoprazole oral suspension granules and mineral oil, which are too viscous and may occlude the tube. Sucralfate suspension is also not suitable because it may cause an insoluble mass or bezoar formation.

Can aspirin be given via NG tube?

Aspirin can be delivered early in crushed form via NG tube after CABG surgery to prevent graft occlusion.

How are medications administered via NG tube?

Connect syringe filled with prescribed dose of medicine to NG tube and push all the medicine in until plunger stops. If the medicine is very sticky, you may draw up 2 to 5 mL of warm water into the medicine syringe. Gently shake the syringe to mix the water and remaining medicine and push it again through the tube.

Can you take aspirin with phenytoin?

The addition of aspirin will produce no change in the free phenytoin concentration and thus no phenytoin toxicity (20 , 21) .

Should phenytoin be taken with food?

You can take it with or without food. The most common side effects of phenytoin are headaches and feeling dizzy.

Can Levaquin be given via PEG tube?

When levoFLOXacin as the oral solution is given with enteral (tube) feedings, levoFLOXacin may not work as well. You could interrupt the feeding for 1 hour before and 2 hours after the levoFLOXacin dose. However, this still may not entirely avoid the interaction and may not always be feasible.

What is nasogastric tube?

What Is a Nasogastric Tube? A nasogastric (NG) tube is a thin, soft tube that goes in through the nose, down the throat, and into the stomach. They’re used to feed formula to a child who can’t get nutrition by mouth. Sometimes, kids get medicine through the tube.

Can you give phenytoin suspension through NG tube?

Suspension (90mg/5mL) is available for NG administration or those with swallowing problems. Dose conversion is however required and interaction with other medications and NG feed can occur. Contact clinical pharmacist for assistance when using suspension and/or NG administration. Phenytoin Administration via Enteral Feeding Tubes

Is phenytoin absorption affected by enteral tube feedings?

Though the mechanism of the interaction is poorly understood, phenytoin absorption is reduced when given concomitantly with enteral tube feedings. This article reviews strategies that may help maintain phenytoin levels when enteral nutrition is required.

When was the interaction between phenytoin and Ng feedings first reported?

This interaction was first reported by Bauer [ 29] in 1982 among neurosurgical patients receiving both continuous NG feedings and phenytoin suspension; subtherapeutic serum phenytoin concentrations were noted.

How does phenytoin interact with other medications in the gastrointestinal system?

The gastrointestinal absorption of phenytoin (PHT), an antiepileptic drug, is often affected by its interaction with co-administered enteral nutrients through a nasogastric (NG) tube, resulting in decreased plasma PHT concentration.