Is gout an autoimmune disease?
Gout is also an inflammatory disorder, but it is not an autoimmune condition. Instead, a person develops gout because of high levels of uric acid in their blood. Uric acid is present in foods and drinks. Taking certain medications can also increase the amount of uric acid in the body.
What diseases does a positive ANA test indicate?
Conditions that usually cause a positive ANA test include:
- Systemic lupus erythematosus.
- Sjögren’s syndrome — a disease that causes dry eyes and mouth.
- Scleroderma — a connective tissue disease.
- Rheumatoid arthritis — this causes joint damage, pain, and swelling.
- Polymyositis — a disease that causes muscle weakness.
Does ANA test for inflammation?
Instead, as part of the diagnosis process, doctors will order several blood tests to measure levels of inflammation, the presence of various antibodies, and more. The antinuclear antibody (ANA) test is one of many blood tests that your rheumatologist might order to help guide the diagnosis.
What does an ANA test rule out?
The antinuclear antibody (ANA) blood test identifies a specific protein in the bloodstream. It can help guide the diagnosis of certain conditions. Doctors often use it to rule out lupus or other autoimmune disorders. The immune system produces antibodies that fight unwanted invaders to keep the body healthy.
Can gout cause positive ANA?
Reporting a titer 1:40 as positive can lead to a very high frequency of false positive ANA results, noted in up to 32% of samples. In general, ANA titers are not useful to monitor autoimmune disease activity….Table 2.
| Serology | Rheumatic Disease |
|---|---|
| Anti-Centromere | Limited Scleroderma |
| Anti-topoisomerase (Scl-70) | Scleroderma |
What autoimmune disease causes gout?
Rheumatoid arthritis is an autoimmune disease in which the immune system mistakenly attacks tissues, inflaming joints. In gout, the body produces too much uric acid or has problems flushing it out, and urate crystals build up in joints, causing inflammation and intense pain.
What is considered a high ANA titer?
A titer of 1:160 or above is commonly considered a positive test result. Other conditions with ANA associations include Crohn’s disease, mononucleosis, subacute bacterial endocarditis, tuberculosis, and lymphoproliferative diseases.
Are gout and arthritis related?
Gout is a common form of inflammatory arthritis that is very painful. It usually affects one joint at a time (often the big toe joint). There are times when symptoms get worse, known as flares, and times when there are no symptoms, known as remission.
Can obesity cause positive ANA?
While this inverse relationship remains among obese participants with low CRP, when these obese and overweight participants are ANA positive, it is associated with greater total body and trunk fat.