What activates PTEN?
PTEN Is Activated by the dCas9-VPR System in SK-MEL-28 Melanoma and SUM159 TNBC Cell Lines. (A) PTEN mRNA expression in a panel of BRAF mutant melanoma and TNBC cell lines.
What is PTEN phosphorylate?
The tumor suppressor function of the PTEN protein (PTEN) has been linked to its ability to dephosphorylate the lipid second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway.
Why is PTEN a tumor suppressor?
PTEN acts as a tumor suppressor gene through the action of its phosphatase protein product. This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly. It is a target of many anticancer drugs.
Is PTEN an oncogene or tumor suppressor?
Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered as a tumor suppressor with growth and survival regulatory functions.
How is PTEN regulated?
The molecular mechanisms regulating PTEN expression and function include transcriptional regulation, post-transcriptional regulation by microRNAs (miRNAs) and competitive endogenous RNA (ceRNAs), post-translational modifications and protein interactions.
What does PTEN stand for?
Causes. PHTS is caused by a germline mutation of PTEN, a tumor suppressor gene. PTEN stands for phosphatase tensin homologue. A tumor suppressor is a gene that slows down cell division, repairs damage to the DNA of cells, and tells cells when to die, a normal process called apoptosis.
What is the function of PTEN?
The PTEN gene provides instructions for making an enzyme that is found in almost all tissues in the body. The enzyme acts as a tumor suppressor, which means that it helps regulate cell division by keeping cells from growing and dividing (proliferating) too rapidly or in an uncontrolled way.
What is PTEN stand for?
PTEN stands for Phosphatase and TENsin homolog deleted on chromosome 10 and is a classical tumor suppressor gene located in the 10q23 region of chromosome 10 encoding for a 403-aminoacid multifunctional protein (predicted MW 47 kDa), which possesses lipid and protein phosphatase activities.
What is CDH1 gene mutation?
What does it mean to have a CDH1 mutation? Having a CDH1 mutation means that you are at high risk for developing a very aggressive form of stomach cancer called hereditary diffuse gastric cancer (HDGC). The CDH1 mutation also puts women at risk for a certain form of breast cancer called lobular breast cancer.
What is PTEN function?