What is p15 protein?
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.
What is p15 cancer?
P15, a novel tumor-suppressor gene, has been reported to play an important regulatory role in the progression of various malignant tumors, such as pulmonary cancer, nasopharynx cancer, and kidney cancer [7].
Is p21 a tumor suppressor gene?
p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential.
Is p21 a tumor suppressor gene or oncogene?
p21 induction has been shown to be crucial for promoting cancer cell motility and tumorigenesis [22]. Therefore, p21 can be an oncogenic protein or a tumor suppressor, depending on its localization in the cytoplasm or the nucleus, respectively [23,24].
Is p15 a tumor suppressor gene?
A complex genomic region at 9p21 (INK4A-ARF-INK4B locus) encodes p14ARF, p15, and p16 proteins, which all act as negative cell cycle regulators and are considered as potential tumor suppressor genes [10].
What does cyclin B do?
Cdk1/cyclin B (also referred to as maturation promoting factor or MPF) is one of the main protein kinases that becomes activated and serves as master regulator for the M-phase transition, phosphorylating and activating other downstream protein kinases, and directly posphorylating several structural proteins involved in …
How do cyclin dependent kinase inhibitors work?
A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK). Several function as tumor suppressor proteins. Cell cycle progression is delayed or stopped by cyclin-dependent kinase inhibitors, abbreviated CDIs, CKIs or CDKIs.
What happens if Rb is phosphorylated?
Rb proteins can be phosphorylated both on A/B domains of the pocket region and on the C-terminal domain. The main hypothesis is that the phosphorylation at the carboxy terminus of pRb by cyclin D/cdk4 (or ckd6) causes a conformational modification, which displaces the HDAC bound to pRb through its LXCXE motif.