What is starch in pharmacy?
Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule disintegrant, a glidant, or as binder. Starches are also used in the food manufacturing industry for processing, and as food thickeners or stabilizers.
What is the difference between starch and pregelatinized starch?
An alternative to native corn starch or polymers for wet granulations is pregelatinized starch. This is a starch that has been previously gelatinized and dried to powder form. Partially pregelatinized starches on the other hand, have a mixture of properties of both native and fully gelatinized starches.
What starch is used in tablets?
Maize and potato starches are the most commonly used starch types for this purpose. However, empirical evaluations of starches from other botanical sources has also shown potential as effective disintegrant in oral rapid release tablets and capsules [49, 50].
What is pregelatinized?
Pregelatinized starch (Dextrin) is starch which has been cooked and then dried in the starch factory on a drum dryer or in an extruder making the starch cold-water-soluble.
What is starch industry?
Starch industry is a part of food processing which is using starch as a starting material for production of starch derivatives, hydrolysates, dextrins. At first, the raw material for the preparation of the starch was wheat.
Is starch structural?
Starch is composed of two types of polymer chains known as amylose and amylopectin. Amylose possesses a linear structure with α1–4 glycosidic linkage while amylopectin possesses a branched structure with α1–4 as well as α1–6 glycosidic linkages (Figure 1) [16, 17].
What is the role of pregelatinized starch?
Starch and pregelatinized starch are used primarily as binders to improve tablet durability and integrity. Pregelatinized starch is partially hydrolyzed and dried to make it flow better during tableting. It also has superior binding characteristics.
What is starch used for?
Aside from their basic nutritional uses, starches are used in brewing and as thickening agents in baked goods and confections. Starch is used in paper manufacturing to increase the strength of paper and is also used in the surface sizing of paper.
Is starch a good diluent?
As a result of its partial cold water solubility, starch functions exceptionally well in tablet manufacture by wet granulation applications and performs dual functions of both a disintegrant and a binder. As a diluent, starch is used to facilitate subsequent mixing or blending processes in manufacturing operations.
What is the pregelatinized starch?
Pregelatinized starch is Physically modified starch, it is partially soluble in Cold water. Pregelatinized starch is widely used in pharmaceutical because it is bland, odourless and capable of digestion. Pregelatinized starch is widely used as a pharmaceutical aid, especially as a filler-binder.
What is sodium starch glycolate?
Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility.
What is a starch 1500 excipient?
Starch 1500 is a proven and trusted unique pharmaceutical excipient, manufactured exclusively for the global pharmaceutical industry. Starch 1500 is particularly effective with moisture sensitive actives and low dose applications.
What are the functions of starch excipients?
Multifunctional starch excipients, such as Starch 1500® partially pregelatinized maize starch and Star Cap 1500® co-processed starch excipient can serve as binders, disintegrants, flow aids, lubricants and/or taste masking.
What is co-Processed starch excipients used for?
Provides excellent stability for moisture sensitive drugs and cost eu001eective content uniformity as a carrier for low dose APIs. StarCap 1500® co-processed starch excipient is a mix of globally accepted excipients (corn starch and pregelatinized starch) designed for use in capsules and tablets.
What is starch?
Starch has been investigated as an excipient in novel drug delivery systems for nasal, oral, periodontal, and other site-specific delivery systems. Depending on the application, specific starches are available for use as disintegrants, fillers or binders.