Which leprosy drug can cause reddish black discoloration of the skin?
Clofazimine may cause orange-pink to brownish-black discoloration of the skin within a few weeks after you start using it. Because of the skin discoloration, some patients may become depressed. It may also cause your sweat, tears, spit, urine, stools, and the whites of your eyes to turn red or brownish-black in color.
Which antibiotic is used to treat leprosy?
Hansen’s disease is treated with a combination of antibiotics. Typically, 2 or 3 antibiotics are used at the same time. These are dapsone with rifampicin, and clofazimine is added for some types of the disease. This is called multidrug therapy.
How does dapsone treat leprosy?
It is also used with other drugs to treat Hansen’s disease. Dapsone belongs to a class of drugs known as sulfones. It works by decreasing swelling (inflammation) and stopping the growth of bacteria.
Does dapsone cure leprosy?
Dapsone is used to treat leprosy (Hansen’s disease) and to help control dermatitis herpetiformis, a skin problem. When it is used to treat leprosy, dapsone may be given with one or more other medicines. Dapsone may also be used for other conditions as determined by your doctor.
What is clofazimine made of?
Clofazimine is 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group.
How does clofazimine work for leprosy?
Clofazimine is a drug used to treat leprosy. It can slow down the growth and weakly kill Mycobacterium leprae, the bacterium that causes leprosy. It is used in combination with rifampicin and dapsone for the treatment of the many forms of leprosy.
What is the chemical name of phenazine?
?) Phenazine is an organic compound with the formula (C 6 H 4) 2 N 2. It is a dibenzo annulated pyrazine, and the parent substance of many dyestuffs, such as the toluylene red, indulines, and safranines (and the closely related eurhodines).
How do you make phenazine?
Classically phenazine are prepared by the reaction of nitrobenzene and aniline in the Wohl-Aue reaction). Other methods include: pyrolysis of the barium salt of azobenzoate. oxidation of aniline with lead oxide. oxidation of dihydrophenazine, which is prepared by heating pyrocatechin with o-phenylenediamine.
What is phenazine-1-carboxylic acid and how is it produced?
Similarly, phenazine-1-carboxylic acid, produced by a number of Pseudomonas, increases survival in soil environments and has been shown to be essential for the biological control activity of certain strains. Phenazine biosynthesis branches off the shikimic acid pathway at a point subsequent to chorismic acid.
Can phenazine derivatives be used in RFB cells?
The first report using a phenazine derivative in an RFB was a symmetric cell, with a bipolar electrolyte consisting of a phenazine center with two TEMPO subunits connected via triethylene glycol (TEG) linkers ( Fig. 9 A) ( Winsberg et al., 2016 ).