Which of the following is hydrophilic polymer used for drug delivery?
Hydrogels are hydrophilic (co)polymeric networks capable of imbibing large amounts of water or biological fluids (38).
Which polymer is used for controlled drug delivery?
Among the synthetic and biodegradable polymers, aliphatic polyesters such as poly (glycolic acid), poly (lactic acid), poly (caprolactone) and polydioxanone, are most commonly used and applied to drug delivery systems.
Why are polymers used in drug delivery?
The main role of polymer is to protect drug from physiological environment and prolong release of drug to improve its stability. The drug is release from polymer by diffusion, degradation and swelling.
What type of polymer would you use to attach a hydrophobic drug?
Thermosensitive hydrogels are usually triblock polymers made up from poly(ethylene glycol) (PEG) linked to hydrophobic polymer blocks.
What are hydrophilic polymers?
Hydrophilic polymers contain polar or charged functional groups, rendering them soluble in water. Semisynthetic water-soluble polymers are derived by either chemical modification of natural polymers or from microbial sources.
Which among the following can be used as a hydrophobic matrix to formulate controlled release drug delivery system?
Hydroxypropylmethlcellulose (HPMC) is a semi-synthetic polymer (Colombo 1993, Ferrero-Rodriquez et al. 2000, Siepmann and Peppas 2001a). It is used as first choice for the formulation of hydrophilic matrix systems as it provides a robust mechanism for controlled release of drugs and choice of viscosity grades.
How are transdermal medications delivered to a patient?
Transdermal drug delivery (TDD) has been focused on a medicating advantage as the promising topical method for medical treatment without patient intention. The transdermal drug passes through the surface layers of the skin and reaches blood capillaries, which distribute the bottom layer of the skin.
What are the potential problems side effects for patients receiving medication via the transdermal route?
Incidence not known
- Agitation.
- darkening of the skin.
- headache.
- lightheadedness, dizziness, or fainting.
- mental depression.
- overactive reflexes.
- poor coordination.
- severe vomiting.
Which polymer is not used as hydrophilic polymer?
Notably, there is a broad variety of hydrophobic polymers that is not considered to be hydrophilic at all, e.g., poly(styrene) or poly(methyl methacrylate). Contrarily, there are various polymers considered to be hydrophilic, e.g., poly(acrylamide) or poly(ethylene glycol) (PEG).
What is an example of a hydrophilic substance?
Examples of hydrophilic liquids include ammonia, alcohols, some amides such as urea and some carboxylic acids such as acetic acid.
What are the advantages of the dual hydrophilic/hydrophobic polymer network segments?
The dual hydrophilic/hydrophobic polymer network segments provide for the required high lubricity and improved mechanical (bulk) properties, respectively.
Hydrophilic polymers are a major area of polymer research with prominent fields of application, e […] Content may be subject to copyright. ]. As such, studies regarding hydrophilic polymers are an important part of polymer science.
What is a dual-structure combination used for?
Such a dual-structure combination can be used to design a new type of lubricious polymer coatings consisting of a hydrophobic polymer network containing hydrophilic polymer segments (chains or loops) at the surface.
How do hydrophilic precursors affect the lubricating properties of polyethylene glycol?
The presence of the hydrophilic precursors as elastically active network components (PEG segments) also greatly enhanced the lubricating properties, but generally to a lesser extent.