Can daptomycin be used for osteomyelitis?
This analysis suggests that daptomycin is an effective and well-tolerated treatment option for osteomyelitis and highlights the importance of optimal surgical intervention and appropriate microbiological diagnosis for clinical outcomes.
Does daptomycin cover MRSA?
Daptomycin is a cyclic lipopeptide antibiotic derived from the organism Streptomyces roseosporus. Daptomycin is used to treat various bacterial infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
How osteomyelitis is diagnosed?
The preferred diagnostic criterion for osteomyelitis is a positive bacterial culture from bone biopsy in the setting of bone necrosis. Magnetic resonance imaging is as sensitive as and more specific than bone scintigraphy in the diagnosis of osteomyelitis.
Is MRSA the same as osteomyelitis?
Methicillin-resistant Staphylococcus aureus (MRSA) is often found to be the causative pathogenic organism in cases of osteomyelitis8,9.
Does linezolid treat osteomyelitis?
Conclusion: Linezolid iv or po was successful in treating patients with osteomyelitis caused by resistant grampositive organisms or those with intolerance or nonresponsiveness to other potentially effective treatments. Larger comparator controlled studies should be performed to confirm these findings.
What should be monitored while on daptomycin?
Patients receiving daptomycin should be monitored for the development of muscle pain or weakness. Consideration should be given to temporarily suspending agents associated with rhabdomyolysis.
What are the three categories of osteomyelitis?
Traditionally, osteomyelitis is a bone infection that has been classified into three categories: (1) a bone infection that has spread through the blood stream (Hematogenous osteomyelitis) (2) osteomyelitis caused by bacteria that gain access to bone directly from an adjacent focus of infection (seen with trauma or …
What is MRSA osteomyelitis?
MRSA osteomyelitis is usually acquired by spread from a contiguous focus of infection and is often polymicrobic in nature. Treatment with vancomycin or vancomycin plus tobramycin when the infection was polymicrobic was effective. The combination of vancomycin plus tobramycin is potentially nephrotoxic.
How is MRSA in the bone treated?
MRSA is often isolated from bone infections and is usually treated with vancomycin, a glycopeptide that inhibits cells wall synthesis of S. aureus in a manner different from that for β-lactams. However, vancomycin-resistant S.
Is daptomycin an effective treatment for osteomyelitis?
Osteomyelitis is a complex and heterogeneous group of infections that require surgical and antimicrobial interventions. Because treatment failure or intolerance is common, new treatment options are needed. Daptomycin has broad Gram-positive activity, penetrates bone effectively and has bactericidal activity within biofilms.
What is the efficacy of daptomycin for the treatment of MRSA?
Daptomycin was used empirically in 105 (48%) patients, with MRSA being the suspected primary pathogen in 74/105 (70%). Culture results were obtained for 189/220 (86%) before or shortly after initiation of therapy with daptomycin.
How is daptomycin used to treat orthopaedic device-related infections?
Orthopaedic device-related infections are complex and require a careful combination of surgical intervention and antimicrobial therapy. Daptomycin, a cyclic lipopeptide, effectively penetrates soft tissue and bone and demonstrates rapid concentration-dependent bactericidal activity against Gram-positive pathogens.
When is rifampin indicated in the treatment of MRSA osteomyelitis?
For patients with concurrent bacteremia, rifampin should be added after bacteremia has cleared. The optimal duration of therapy for MRSA osteomyelitis is unknown, although a minimum of eight weeks is recommended.