What does MTHFR deficiency mean?

What does MTHFR deficiency mean?

Homocystinuria due to MTHFR deficiency is a genetic condition that results from poor metabolism of folate (also called vitamin B9), due to a lack of working enzyme called MTHFR. The gene that tells our body how to make the enzyme is also called MTHFR.

What is methyl tetrahydrofolate reductase?

The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving the vitamin folate (also called vitamin B9).

How common is MTHFR deficiency?

The most common MTHFR mutation is called the MTHFR C677T mutation. The mutation is extremely common in certain ethnic and geographic populations. In the United States, ≈20% to 40% of white and Hispanic individuals are heterozygous for MTHFR C677T. The mutation is less common in blacks (1%–2%).

What is the C677T mutation?

The MTHFR C677T variant affects how your body processes folate. You might have read or heard that folic acid is not safe if you have one or two copies of the MTHFR C677T variant.

How do you know if you have methylation issues?

Fatigue is perhaps the most common symptom of problems with methylation. Other symptoms or conditions can include: Anxiety. Depression.

How do you treat MTHFR?

Natural treatments for MTHFR mutation symptoms

  1. Consume more folate and vitamin B12. Consuming more folate in your diet may aid with methylation.
  2. Support detoxification.
  3. Minimize alcohol intake.
  4. Manage your stress with lifestyle changes.
  5. Check your supplements.
  6. Heal any underlying digestive issues.

How to test for MTHFR mutations?

You had a blood test that showed higher than normal levels of homocysteine

  • A close relative was diagnosed with an MTHFR mutation
  • You and/or close family members have a history of premature heart disease or blood vessel disorders
  • What does the MTHFR gene mutation cause?

    The MTHFR gene mutation can cause autoimmune disorders. Since the MTHFR gene mutation causes the body to be less able to methylate, it is hard for the body to detoxify. Toxins in the body can lead to autoimmune disorders. Updated on: December 3rd, 2021 Published on: July 11th, 2017 .

    Do you have problems with methylation?

    Making too much or not enough methyl impairs the ability to think clearly, have meaningful relationships, have a healthy body, and live a fulfilling life. In today’s world, methylation problems are commonplace due to food and environmental toxins, emotional trauma, genetic errors, and stress.

    What does methylenetetrahydrofolate reductase mean?

    Methylenetetrahydrofolate reductase (MTHFR), is an enzyme that works as a catalyst for important biochemical reactions in your body. It converts vitamin B9 (folate) into methyl-folate which is essential for a process called methylation. Every single cell and tissue in your body experiences methylation.