What is a paraganglioma pathology?
Histologically, paragangliomas are characterized by a honeycomb pattern in which well-circumscribed nests (Zellballen) of round-oval or giant multinucleated neoplastic cells with cytoplasmic catecholamine granules are surrounded by S-100-positive supratentorial cells.
Can you biopsy paraganglioma?
However, a tumor suspected to be a pheochromocytoma or paraganglioma should not have a biopsy, unless it is absolutely necessary to confirm a diagnosis. A biopsy of these tumors can cause a serious and even life-threatening release of catecholamines.
How fast do paragangliomas grow?
14, 17 The variation in the growth rate of growing paragangliomas is remarkable; we estimated a Td between 0.6–21.5 years. This observation was made in malignant tumors as well and can be explained in part by the influence of tumor size on growth rate.
Is paraganglioma a terminal?
Paraganglioma of the filum terminal/cauda equina is a rare slow growing tumor which originates from the ectopic sympathetic neurons. Surgically, total excision may be difficult for this well demarcated tumor surrounded by couple of rootlets but is usually possible in nearly all cases.
How fast do pheochromocytomas grow?
Most people develop a pheochromocytoma in 1 adrenal gland. Some people develop a tumor in both glands. There can also be multiple tumors in a gland. Pheochromocytomas usually grow slowly.
Can we predict the prognosis of paragangliomas?
Paragangliomas: assessment of prognosis by histologic, immunohistochemical, and ultrastructural techniques To predict clinical outcome, we studied 42 paragangliomas from 37 patients by routine histology, immunohistochemistry, and electron microscopy.
What are the signs and symptoms of paraganglioma?
May show symptoms depending on specific neuropeptide production, if functional (i.e. hypertension from elevated norepinephrine) If metastases, call “malignant paraganglioma”, which may show reduced sustentacular cells and decreased neuropeptide markers
What is an immunohistochemical panel for the diagnosis of paraganglioma?
The use of an immunohistochemical panel, in addition to routine histology, can confirm the diagnosis of a paraganglioma and can give an indication of the likely prognosis for a patient. MeSH terms Adolescent Adult Aged
What is the pathophysiology of glomus tympanicum tumor?
Usually arise lateral in temporal bone (glomus tympanicum tumor) or jugular bulb (glomus jugulare tumor), erode through floor and present as mass of external auditory canal or middle ear; also mass at base of skull, middle ear “polyps” Round / oval cells and giant multinucleated cells with abundant granular eosinophilic or basophilic cytoplasm