What is adipose tissue dysfunction?

What is adipose tissue dysfunction?

Dysfunction of adipose tissue can result in insulin resistance and its metabolic complications in patients with excess body fat (obesity) or markedly reduced body fat (lipodystrophy). Alterations in free fatty acid and adipocytokine release from adipose tissue may underlie metabolic complications.

What increases adipose tissue?

Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Moreover, high-fat feeding increases the rate of adipose cell size growth, independent of strain, reflecting the increase in calories requiring storage.

What happens when adipose tissue is damaged?

More commonly, too much adipose tissue leads to obesity, mainly from too much visceral fat. Obesity leads to a number of serious health problems. Obesity increases the risk of developing type 2 diabetes as it causes the body to become resistant to insulin.

How do you increase adipose tissue?

Regular exercise training has been shown, both in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), to reduce adipose tissue mass,4 5 adipocyte hypertrophy, adipose tissue inflammation6 and increase mitochondrial function and biogenesis7 in humans and rodents.

What causes adipose tissue dysfunction?

The majority of patients with obesity have an impaired adipose tissue function caused by the interaction of genetic and environmental factors which lead to adipocyte hypertrophy, hypoxia, a variety of stresses and inflammatory processes within adipose tissue.

What is the treatment for adipose tissue?

A major mechanism of insulin-sensitizing agents such as thiazolidinediones is to reduce inflammation in adipose tissue[76-78]. When human T1D patients are treated with insulin replacement, either directly or through transplantation of insulin secreting tissue, there is recovery of adipose tissue[79,80].

How can I increase my adipose tissue in my breast?

Increasing the food energy intake by eating more and/or more energetic foods. By increasing food energy intake, more adipose tissue will be created, part of which will consist of adipose tissue located near the breast area.

What does adipose tissue look like?

Adipose tissue in the adult human appears white or yellowish in colour. During preparation of H & E slides the fat is dissolved and the cell appears empty, with a very thin rim of cytoplasm and the nucleus along the edge. This appearance is described as “signet ring” appearance.

What disease eats your fat cells?

Lipodystrophy is a condition in which the amount and/or distribution of adipose tissue (fat tissue) in the body is abnormal. Different types of lipodystrophy cause loss or re-distribution of fat tissue in different patterns.