What is the Aurka gene?
AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include Colorectal Cancer and Colorectal Adenocarcinoma. Among its related pathways are EGF/EGFR Signaling Pathway and Cell cycle_Chromosome condensation in prometaphase.
What does Aurora A do?
Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation.
Is Alisertib FDA approved?
However, alisertib is not currently approved by the Food and Drug Administration (FDA) in the United States for lymphoma. With regard to pralatrexate, which is FDA approved for relapsed or refractory PTCL, the phase 1 and 2 trials cumulatively included 3 subjects with ATLL.
What does Aurora A kinase do?
Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation.
What does polo kinase do?
The Polo Kinase is a central regulator of cell division required for several events of mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) comprise a Polo-Box domain (PBD), which mediates protein interactions with targets and regulators of Plks.
Where can you find Aurora A in mitosis?
centrosomes
Indeed, Aurora A is located to centrosomes in G2 and both to centrosomes and to mitotic spindle poles during mitotic spindle assembly. Interestingly, the kinase is also found associated with the central spindle and later on the midbody during mitotic exit.
What does Aurora B kinase do?
Aurora B is a mitotic checkpoint kinase that plays a pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis. Aurora B is overexpressed in many types of human cancers, which has made it an attractive target for cancer therapies.
Are centrosomes essential?
Aren’t centrosomes essential for all cells? No. Centrosomes are not essential in somatic cells in fruit flies, and many animal cells don’t have them (reviewed in [16]). Most eukaryotic cells do have a microtubule cytoskeleton but this can be organized in many different ways by MTOCs, which need not be centrosomes.
What is the role of AURKA in cancer?
AURKA shows significantly higher expression in cancer tissues than in normal control tissues for multiple tumor types according to the TCGA database. Activation of AURKA has been demonstrated to play an important role in a wide range of cancers, and numerous AURKA substrates have been identified.
Which types of cancer show AURKA with log2 values < 2?
Four out of 33 (12.1%) cancer types show expression of AURKA with log2 (transcripts per million [TPM] + 1) values < 2, including brain lower-grade glioma (LGG), prostate adenocarcinoma (PRAD), pheochromocytoma and paraganglioma (PCPG) and THCA versus other tumors.
Can tanshinone I target AURKA?
Although there is no direct evidence that tanshinone I can directly target AURKA, it exhibits potent effects on growth inhibition of colon cancer [ 233 ], lung cancer [ 234] and breast cancer cells [ 235] through downregulating AURKA expression.
How is AURKA activated by Withanone?
AURKA can be activated by its protein partners, among which TPX2 is the best established one. Withanone is an herbal ligand isolated from ashwagandha. Withanone is reported to bind to the TPX2/AURKA complex which results in the dissociation of TPX2 from AURKA and disruption of mitotic spindle apparatus in cancer cells [ 236 ].